Nucleosome Shape Dictates Chromatin Fiber Structure
نویسندگان
چکیده
منابع مشابه
Nucleosome shape dictates chromatin fiber structure.
In addition to being the gateway for all access to the eukaryotic genome, chromatin has in recent years been identified as carrying an epigenetic code regulating transcriptional activity. Though much is known about the biochemistry of this code, little is understood regarding the different fiber structures through which the regulation is mediated. Over the last three decades many fiber models h...
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Chromatin nucleosomes (mononucleosomes through pentanucleosomes) have been isolated by staphylococcal nuclease digestion of calf thymus nuclei. The peak value ellipticity is the same for all oligomers, 1900 deg cm2, mol"* at 280 nm, 23°C. The dh28Q,/dT vs T show a progressive increase in Tm of the main thermal band (73.5 C, monomer; 79 C, pentamer). Very small amounts of free DNA can be observe...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2009
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2008.09.055